MuScle-logoMuScle - Molecule ID BJ988

geneHHCMA56, WWOX, FOR
nameWW domain-containing oxidoreductase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
WWOX_HUMANQ9NZC7ENSG0000018615351741Hs.461453133239, 605131

Functions and classifications

GOC:cytosol, C:Golgi apparatus, C:mitochondrion, C:nucleus, F:coenzyme binding, F:oxidoreductase activity, F:protein dimerization activity, P:cellular response to transforming growth factor beta stimulus, P:extrinsic apoptotic signaling pathway, P:intrinsic apoptotic signaling pathway by p53 class mediator, P:negative regulation of Wnt signaling pathway, P:osteoblast differentiation, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:positive regulation of transcription from RNA polymerase II promoter, P:skeletal system morphogenesis, P:steroid metabolic process, P:Wnt signaling pathway, P:oxidation-reduction process, F:nucleotide binding, P:apoptotic process, P:induction of apoptosis, P:negative regulation of Wnt receptor signaling pathway, P:Wnt receptor signaling pathway
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Disease mutation, Golgi apparatus, Mitochondrion, NADP, Nucleus, Oxidoreductase, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Tumor suppressor, Ubl conjugation, Wnt signaling pathway
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.911.88E-0222021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.190.040718722252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.331.21E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.903.30E-0622252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)4.990.0251401122491253
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.073.05E-0223895517

Compile date 09-07-2016© MuScle project