MuScle-logoMuScle - Molecule ID BJ692

geneALOX5, LOG5
nameArachidonate 5-lipoxygenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LOX5_HUMANP09917ENSG00000012779|ENSG00000262552240Hs.89499152390

Functions and classifications

GOC:cytosol, C:nuclear envelope lumen, C:nuclear matrix, C:nuclear membrane, F:arachidonate 5-lipoxygenase activity, F:iron ion binding, P:arachidonic acid metabolic process, P:leukotriene biosynthetic process, P:leukotriene production involved in inflammatory response, P:lipoxin metabolic process, P:lipoxygenase pathway, C:dendrite, C:sarcolemma, F:lipoxygenase activity, P:acute inflammatory response, P:positive regulation of vasoconstriction, P:response to hyperoxia, P:response to nutrient, P:sensory perception of pain, P:leukotriene metabolic process, C:cytoplasm, C:nucleus
UniProt3D-structure, Alternative splicing, Calcium, Complete proteome, Cytoplasm, Dioxygenase, Direct protein sequencing, Iron, Leukotriene biosynthesis, Membrane, Metal-binding, Nucleus, Oxidoreductase, Phosphoprotein, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.884.58E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.220.006495820136355
Exp21346816Homo sapiens12Blood MS (Multiple sclerosis)0.780.04300621346816
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.264.56E-0321886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.031.30E-1322252466
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)1.860.015099922491253

Compile date 09-07-2016© MuScle project