MuScle-logoMuScle - Molecule ID BJ595

geneABAT, GABAT
name4-aminobutyrate aminotransferase, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
GABT_HUMANP80404ENSG0000018304418Hs.336768137150, 613163

Functions and classifications

GOC:4-aminobutyrate transaminase complex, C:mitochondrial matrix, C:neuron projection, F:(S)-3-amino-2-methylpropionate transaminase activity, F:4-aminobutyrate transaminase activity, F:pyridoxal phosphate binding, F:succinate-semialdehyde dehydrogenase binding, P:behavioral response to cocaine, P:copulation, P:gamma-aminobutyric acid catabolic process, P:locomotory behavior, P:negative regulation of blood pressure, P:neurotransmitter catabolic process, P:neurotransmitter secretion, P:response to drug, P:response to ethanol, P:response to hypoxia, P:response to iron ion, P:response to nicotine, P:gamma-aminobutyric acid metabolic process
UniProtAcetylation, Aminotransferase, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Mitochondrion, Neurotransmitter degradation, Polymorphism, Pyridoxal phosphate, Reference proteome, Transferase, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)1.200.038141120136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.290.017699920136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.693.71E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.711.26E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.243.83E-0222021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.752.83E-0222252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.102.42E-0223895517

Compile date 09-07-2016© MuScle project