MuScle-logoMuScle - Molecule ID BJ440

geneA7322, ARFGEF3, BIG3
nameBrefeldin A-inhibited guanine nucleotide-exchange protein 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
BIG3_HUMANQ5TH69ENSG0000011237957221Hs.194408

Functions and classifications

GOC:integral component of membrane, C:trans-Golgi network, F:ARF guanyl-nucleotide exchange factor activity, P:negative regulation of phosphatase activity, P:regulation of ARF protein signal transduction, P:vesicle-mediated transport, P:regulation of GTPase activity, C:integral to membrane, C:intracellular
UniProtComplete proteome, Guanine-nucleotide releasing factor, Membrane, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix, Phosphoprotein
PADBMOD: modulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.870.02049721886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.154.66E-0322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.264.90E-0422252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.340.026715322491253
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)3.930.035866322491253

Compile date 09-07-2016© MuScle project