MuScle-logoMuScle - Molecule ID BJ439

geneBID
nameBH3 interacting domain death agonist
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BID_HUMANP55957ENSG00000015475637Hs.591054601997

Functions and classifications

GOC:cytosol, C:integral component of mitochondrial membrane, C:mitochondrial outer membrane, F:death receptor binding, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:brain development, P:establishment of protein localization to membrane, P:extrinsic apoptotic signaling pathway via death domain receptors, P:glial cell apoptotic process, P:intrinsic apoptotic signaling pathway, P:neuron apoptotic process, P:positive regulation of apoptotic process, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of mitochondrial outer membrane permeabilization, P:positive regulation of protein homooligomerization, P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, P:positive regulation of release of cytochrome c from mitochondria, P:protein homooligomerization, P:protein targeting to mitochondrion, P:regulation of cell proliferation, P:regulation of G1/S transition of mitotic cell cycle, P:regulation of mitochondrial membrane permeability involved in apoptotic process, P:release of cytochrome c from mitochondria, P:response to estradiol, P:signal transduction in response to DNA damage, P:extrinsic apoptotic signaling pathway, C:cytoplasm, C:integral to mitochondrial membrane, P:regulation of mitochondrial membrane permeability, P:response to estradiol stimulus
UniProt3D-structure, Acetylation, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Membrane, Mitochondrion, Phosphoprotein, Polymorphism, Reference proteome, Ubl conjugation
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.190.005677820136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.759.83E-0321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)2.283.43E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.265.99E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.361.05E-0422021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.330.012693422252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.264.23E-0922252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.341.08E-1022252466

Compile date 09-07-2016© MuScle project