MuScle-logoMuScle - Molecule ID BJ400

geneACSL3, ACS3, FACL3
nameLong-chain-fatty-acid--CoA ligase 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACSL3_HUMANO95573ENSG000001239832181Hs.655772602371

Functions and classifications

GOC:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:Golgi apparatus, C:integral component of membrane, C:lipid particle, C:mitochondrial outer membrane, C:perinuclear region of cytoplasm, C:peroxisomal membrane, F:ATP binding, F:long-chain fatty acid-CoA ligase activity, P:brain development, P:fatty acid biosynthetic process, P:long-chain fatty acid import, P:positive regulation of Golgi to plasma membrane protein transport, P:positive regulation of phosphatidylcholine biosynthetic process, P:positive regulation of secretion, P:response to nutrient, P:response to organic cyclic compound, P:very-low-density lipoprotein particle assembly, F:catalytic activity, F:ligase activity, C:integral to membrane, P:long-chain fatty-acyl-CoA biosynthetic process, P:triglyceride biosynthetic process, P:long-chain fatty acid metabolic process
UniProtATP-binding, Complete proteome, Endoplasmic reticulum, Fatty acid metabolism, Ligase, Lipid metabolism, Magnesium, Membrane, Microsome, Mitochondrion, Mitochondrion outer membrane, Nucleotide-binding, Peroxisome, Phosphoprotein, Polymorphism, Reference proteome, Signal-anchor, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.241.03E-0220136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.450.049827921886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.643.69E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.380.00822821886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.390.0125002121886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.124.40E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.181.32E-0222021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.260.002178522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.509.32E-0822252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.675.34E-0522252466

Compile date 09-07-2016© MuScle project