MuScle-logoMuScle - Molecule ID BJ398

geneACO2
nameAconitate hydratase, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACON_HUMANQ99798ENSG0000010041250Hs.643610100850, 614559

Functions and classifications

GOC:mitochondrial matrix, C:nucleus, F:3 iron, 4 sulfur cluster binding, F:4 iron, 4 sulfur cluster binding, F:aconitate hydratase activity, F:iron ion binding, P:cell death, P:citrate metabolic process, P:isocitrate metabolic process, P:tricarboxylic acid cycle, "F:4 iron, 4 sulfur cluster binding, "C:mitochondrion, F:citrate hydro-lyase (cis-aconitate-forming) activity, F:isocitrate hydro-lyase (cis-aconitate-forming) activity
UniProt4Fe-4S, Acetylation, Complete proteome, Direct protein sequencing, Disease mutation, Iron, Iron-sulfur, Isopeptide bond, Lyase, Metal-binding, Mitochondrion, Neurodegeneration, Phosphoprotein, Polymorphism, Pyrrolidone carboxylic acid, Reference proteome, Transit peptide, Tricarboxylic acid cycle, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)2.054.69E-0417467740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.132.25E-0222021740
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.131.14E-0223895517

Compile date 09-07-2016© MuScle project