MuScle-logoMuScle - Molecule ID BG712

geneALS2CR4, TMEM237
nameAmyotrophic lateral sclerosis 2 chromosomal region candidate gene 4 protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
TM237_HUMANQ96Q45ENSG0000015575565062Hs.12319614423, 614424

Functions and classifications

GOC:ciliary transition zone, C:integral component of membrane, P:cilium assembly, P:regulation of Wnt signaling pathway, C:integral to membrane, P:regulation of Wnt receptor signaling pathway
UniProtAlternative splicing, Cell projection, Ciliopathy, Cilium, Cilium biogenesis/degradation, Complete proteome, Joubert syndrome, Membrane, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix
PADBDEV: development, cell growth, differentiation, morphogenesis

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)1.152.11E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.791.18E-1322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)3.078.18E-1022252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.942.35E-0323895517

Compile date 09-07-2016© MuScle project