MuScle-logoMuScle - Molecule ID BG495

geneALYREF, ALY, BEF
nameTHO complex subunit 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
THOC4_HUMANQ86V81ENSG0000018368410189Hs.534385604171

Functions and classifications

GOC:catalytic step 2 spliceosome, C:cytosol, C:nuclear speck, C:nucleoplasm, C:transcription export complex, F:nucleotide binding, F:RNA binding, P:mRNA 3'-end processing, P:mRNA splicing, via spliceosome, P:positive regulation of DNA-templated transcription, elongation, P:regulation of DNA recombination, P:replication fork processing, P:termination of RNA polymerase II transcription, P:viral mRNA export from host cell nucleus, C:nucleus, F:single-stranded DNA binding, P:intronless viral mRNA export from host nucleus, P:termination of RNA polymerase II transcription", F:nucleic acid binding
UniProt3D-structure, Acetylation, Chaperone, Complete proteome, Cytoplasm, Direct protein sequencing, Host-virus interaction, Methylation, mRNA processing, mRNA splicing, mRNA transport, Nucleus, Phosphoprotein, Reference proteome, RNA-binding, Spliceosome, Transport
PADBCHA: chaperone, chaperonin

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.571.34E-0217467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)0.760.0179216420136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.591.19E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)2.222.57E-0722021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)4.693.70E-1022021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.666.40E-0322252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)1.770.046315922491253
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)1.840.0223982422491253

Compile date 09-07-2016© MuScle project