MuScle-logoMuScle - Molecule ID BF634

geneALDH5A1, SSADH
nameSuccinate semialdehyde dehydrogenase, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
SSDH_HUMANP51649ENSG000001122947915Hs.371723271980, 610045

Functions and classifications

GOC:mitochondrial matrix, F:protein homodimerization activity, F:succinate-semialdehyde dehydrogenase (NAD+) activity, F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity, P:acetate metabolic process, P:central nervous system development, P:galactosylceramide metabolic process, P:gamma-aminobutyric acid catabolic process, P:glucose metabolic process, P:glucosylceramide metabolic process, P:glutamate metabolic process, P:glutamine metabolic process, P:glutathione metabolic process, P:glycerophospholipid metabolic process, P:neurotransmitter catabolic process, P:neurotransmitter secretion, P:post-embryonic development, P:protein homotetramerization, P:respiratory electron transport chain, P:short-chain fatty acid metabolic process, P:succinate metabolic process, C:mitochondrion, F:carboxylic acid binding, F:NAD binding
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Disease mutation, Disulfide bond, Mitochondrion, NAD, Oxidoreductase, Polymorphism, Reference proteome, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.743.24E-0222021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)1.141.02E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.893.24E-1022252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.313.67E-0822252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)4.892.18E-1122252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)2.050.0093876922491253
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)0.540.032068922491253
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.292.31E-0323895517

Compile date 09-07-2016© MuScle project