MuScle-logoMuScle - Molecule ID BE232

geneAML2, RUNX3, CBFA3
nameRUNT-related transcription factor 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
RUNX3_HUMANQ13761ENSG00000020633864Hs.170019600210

Functions and classifications

GOC:cytoplasm, C:nuclear chromatin, F:ATP binding, F:RNA polymerase II regulatory region sequence-specific DNA binding, F:sequence-specific DNA binding RNA polymerase II transcription factor activity, P:axon guidance, P:cell maturation, P:chondrocyte differentiation, P:hair follicle morphogenesis, P:interferon-gamma production, P:negative regulation of cell cycle, P:negative regulation of epithelial cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:peripheral nervous system neuron development, P:positive regulation of extrinsic apoptotic signaling pathway, P:protein phosphorylation, "C:nucleus, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, P:transcription, DNA-templated", P:regulation of transcription, DNA-templated", P:induction of apoptosis, C:nucleus, P:regulation of transcription, DNA-dependent"
UniProtAlternative splicing, Complete proteome, Cytoplasm, DNA-binding, Nucleus, Phosphoprotein, Reference proteome, Transcription, Transcription regulation
PADBTF: transcription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.704.54E-0220136355
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.661.82E-0322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.367.56E-0323895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.462.92E-0323895517

Compile date 09-07-2016© MuScle project