MuScle-logoMuScle - Molecule ID BD139

geneADSL, AMPS
nameAdenylosuccinate lyase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PUR8_HUMANP30566ENSG00000239900158Hs.75527103050, 608222

Functions and classifications

GOC:cytosol, C:mitochondrion, F:(S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate AMP-lyase (fumarate-forming) activity, F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, P:'de novo' AMP biosynthetic process, P:'de novo' IMP biosynthetic process, P:aerobic respiration, P:AMP biosynthetic process, P:protein tetramerization, P:purine nucleobase metabolic process, P:response to hypoxia, P:response to muscle activity, P:response to nutrient, P:response to starvation, "C:cytoplasm, P:purine ribonucleotide biosynthetic process", "F:N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity, C:cytosol, P:response to nutrient", F:lyase activity, P:purine ribonucleotide biosynthetic process
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Epilepsy, Lyase, Purine biosynthesis, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)1.200.01414820921521
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)0.810.037141321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)0.790.0184400621886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.031.14E-0522252466

Compile date 09-07-2016© MuScle project