MuScle-logoMuScle - Molecule ID BC210

geneACAN, AGC1, CSPG1
nameAggrecan core protein precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PGCA_HUMANP16112ENSG00000157766176Hs.2159155760, 165800, 608361, 612813

Functions and classifications

GOC:extracellular region, C:Golgi lumen, C:lysosomal lumen, C:proteinaceous extracellular matrix, F:carbohydrate binding, F:extracellular matrix structural constituent, F:hyaluronic acid binding, F:metal ion binding, P:carbohydrate metabolic process, P:cell adhesion, P:extracellular matrix organization, P:keratan sulfate biosynthetic process, P:keratan sulfate catabolic process, P:proteolysis, P:skeletal system development, F:calcium ion binding, C:basement membrane, P:cartilage condensation, P:chondrocyte development, P:collagen fibril organization, P:proteoglycan biosynthetic process, C:perineuronal net, P:chondroblast differentiation, P:multicellular organismal aging, P:negative regulation of cell migration, P:ossification, P:response to acidity, P:response to drug, P:response to glucose stimulus, P:response to gravity, P:response to mechanical stimulus, P:response to organic cyclic compound, P:response to radiation, P:spinal cord development
UniProt3D-structure, Alternative splicing, Calcium, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Dwarfism, EGF-like domain, Extracellular matrix, Glycoprotein, Immunoglobulin domain, Lectin, Metal-binding, Polymorphism, Proteoglycan, Reference proteome, Repeat, Secreted, Signal, Sushi
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.210.037203521886806
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)1.142.01E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.841.58E-0322252466
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)3.270.034628122491253

Compile date 09-07-2016© MuScle project