MuScle-logoMuScle - Molecule ID B9551

geneABCB4, MDR3, PGY3
nameMultidrug resistance protein 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
MDR3_HUMANP21439ENSG000000054715244Hs.654403171060, 600803, 602347, 614972

Functions and classifications

GOC:apical plasma membrane, C:Golgi membrane, C:integral component of plasma membrane, C:intercellular canaliculus, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:xenobiotic-transporting ATPase activity, P:cellular lipid metabolic process, P:drug transmembrane transport, P:xenobiotic transport, P:response to xenobiotic stimulus, "C:integral component of membrane, P:ATP catabolic process", F:ATPase activity, P:ATP catabolic process, C:membrane, C:integral to plasma membrane, P:response to drug, P:response to glucocorticoid stimulus", C:integral to membrane, "C:integral to membrane, F:ATPase activity, coupled to transmembrane movement of substances", P:response to glucocorticoid stimulus, C:integral component of membrane
UniProtAlternative splicing, ATP-binding, Cell membrane, Complete proteome, Disease mutation, Glycoprotein, Hydrolase, Intrahepatic cholestasis, Membrane, Nucleotide-binding, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.641.42E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.684.13E-0322021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.905.16E-0322252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)2.400.0034945322491253

Compile date 09-07-2016© MuScle project