MuScle-logoMuScle - Molecule ID B9550

geneABCB1, MDR1, PGY1
nameMultidrug resistance protein 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
MDR1_HUMANP08183ENSG000000855635243Hs.489033171050, 612244, 120080

Functions and classifications

GOC:apical plasma membrane, C:cell surface, C:Golgi membrane, C:integral component of membrane, C:intercellular canaliculus, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, F:xenobiotic-transporting ATPase activity, P:drug transmembrane transport, P:G2/M transition of mitotic cell cycle, P:stem cell proliferation, P:xenobiotic transport, "C:integral component of membrane, P:ATP catabolic process", F:ATPase activity, P:ATP catabolic process, C:integral to membrane, P:stem cell proliferation", "C:integral to membrane
UniProtATP-binding, Cell membrane, Complete proteome, Glycoprotein, Hydrolase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix, Transport
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)0.390.023216721886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.422.99E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.463.05E-0221886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)4.061.89E-1322252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)2.360.0196360922491253
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)0.610.048249422491253

Compile date 09-07-2016© MuScle project