MuScle-logoMuScle - Molecule ID B9193

geneALOX15B
nameArachidonate 15-lipoxygenase B
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LX15B_HUMANO15296ENSG00000179593247Hs.111256603697

Functions and classifications

GOC:cytoskeleton, C:cytosol, C:nucleus, C:plasma membrane, F:arachidonate 15-lipoxygenase activity, F:arachidonate 8(S)-lipoxygenase activity, F:iron ion binding, F:linoleate 13S-lipoxygenase activity, P:apoptotic process, P:arachidonic acid metabolic process, P:hepoxilin biosynthetic process, P:linoleic acid metabolic process, P:lipoxygenase pathway, P:negative regulation of cell cycle, P:negative regulation of cell migration, P:negative regulation of cell proliferation, P:negative regulation of growth, P:positive regulation of chemokine secretion, P:positive regulation of keratinocyte differentiation, P:positive regulation of macrophage derived foam cell differentiation, P:positive regulation of peroxisome proliferator activated receptor signaling pathway, P:prostate gland development, P:regulation of epithelial cell differentiation, "F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", C:cytoplasm, C:intracellular, F:lipoxygenase activity, P:fatty acid metabolic process, P:induction of apoptosis, P:leukotriene biosynthetic process, P:leukotriene metabolic process, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
UniProtAlternative splicing, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Dioxygenase, Iron, Membrane, Metal-binding, Nucleus, Oxidoreductase, Polymorphism, Reference proteome, Leukotriene biosynthesis
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.100.0395258221216829
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.692.22E-0522252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.240.0026367422491253

Compile date 09-07-2016© MuScle project