MuScle-logoMuScle - Molecule ID B9192

geneALOX12B
nameArachidonate 12-lipoxygenase, 12R type
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LX12B_HUMANO75342ENSG00000179477242Hs.136574242100, 603741

Functions and classifications

GOC:cytosol, F:arachidonate 12-lipoxygenase activity, F:iron ion binding, F:linoleate 9S-lipoxygenase activity, P:arachidonic acid metabolic process, P:ceramide biosynthetic process, P:establishment of skin barrier, P:hepoxilin biosynthetic process, P:linoleic acid metabolic process, P:lipoxygenase pathway, P:positive regulation of gene expression, P:positive regulation of MAPK cascade, P:positive regulation of mucus secretion, P:protein lipidation, F:lipoxygenase activity, P:epidermis development, P:leukotriene biosynthetic process, P:lipid metabolic process
UniProtComplete proteome, Cytoplasm, Dioxygenase, Disease mutation, Fatty acid metabolism, Ichthyosis, Iron, Lipid metabolism, Metal-binding, Oxidoreductase, Polymorphism, Reference proteome, Leukotriene biosynthesis
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)0.634.68E-0217467740
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.782.25E-0321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.820.01178321886806
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.816.06E-0322252466

Compile date 09-07-2016© MuScle project