MuScle-logoMuScle - Molecule ID B8987

geneALOXE3
nameEpidermis-type lipoxygenase 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LOXE3_HUMANQ9BYJ1ENSG0000017914859344Hs.232770606545, 607206, 242100

Functions and classifications

GOC:cytoplasm, F:hepoxilin A3 synthase activity, F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, P:arachidonic acid metabolic process, P:ceramide biosynthetic process, P:establishment of skin barrier, P:fat cell differentiation, P:hepoxilin biosynthetic process, P:linoleic acid metabolic process, P:lipoxygenase pathway, P:peroxisome proliferator activated receptor signaling pathway, P:sensory perception of pain, "F:metal ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "F:iron ion binding, F:lipoxygenase activity, P:leukotriene biosynthetic process, P:leukotriene metabolic process
UniProtAlternative splicing, Complete proteome, Cytoplasm, Dioxygenase, Disease mutation, Fatty acid metabolism, Ichthyosis, Iron, Isomerase, Lipid metabolism, Metal-binding, Oxidoreductase, Reference proteome, Leukotriene biosynthesis
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)22.000.0365582321216829
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.901.51E-0322021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.848.75E-0422252466

Compile date 09-07-2016© MuScle project