MuScle-logoMuScle - Molecule ID B8986

geneALOX15, LOG15
nameArachidonate 15-lipoxygenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LOX15_HUMANP16050ENSG00000161905246Hs.73809152392

Functions and classifications

GOC:cytosol, C:lipid particle, C:nucleus, C:plasma membrane, F:arachidonate 12-lipoxygenase activity, F:arachidonate 15-lipoxygenase activity, F:eoxin A4 synthase activity, F:iron ion binding, P:apoptotic cell clearance, P:arachidonic acid metabolic process, P:bone mineralization, P:cellular response to interleukin-13, P:hepoxilin biosynthetic process, P:inflammatory response, P:leukotriene metabolic process, P:lipoxin A4 biosynthetic process, P:lipoxygenase pathway, P:negative regulation of adaptive immune response, P:phosphatidylethanolamine biosynthetic process, P:positive regulation of actin filament polymerization, P:positive regulation of cell-substrate adhesion, P:positive regulation of ERK1 and ERK2 cascade, P:regulation of engulfment of apoptotic cell, P:regulation of peroxisome proliferator activated receptor signaling pathway, P:response to endoplasmic reticulum stress, P:wound healing, "F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", "F:metal ion binding, "C:cytoplasm, C:cytoplasm, F:lipoxygenase activity, P:leukotriene biosynthetic process, P:lipid metabolic process, F:hepoxilin-epoxide hydrolase activity, F:metal ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
UniProt3D-structure, Cell membrane, Complete proteome, Cytoplasm, Dioxygenase, Direct protein sequencing, Fatty acid metabolism, Iron, Lipid droplet, Lipid metabolism, Membrane, Metal-binding, Oxidoreductase, Polymorphism, Reference proteome, Leukotriene biosynthesis
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.200.01487122252466

Compile date 09-07-2016© MuScle project