MuScle-logoMuScle - Molecule ID B8985

geneALOX12, LOG12, 12LO
nameArachidonate 12-lipoxygenase, 12S-type
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LOX12_HUMANP18054ENSG00000108839239Hs.654431114500, 133239, 152391

Functions and classifications

GOC:cytosol, C:sarcolemma, F:arachidonate 12-lipoxygenase activity, F:hepoxilin A3 synthase activity, F:hepoxilin-epoxide hydrolase activity, F:iron ion binding, F:linoleate 13S-lipoxygenase activity, P:aging, P:arachidonic acid metabolic process, P:cellular component movement, P:cellular response to lipid, P:establishment of skin barrier, P:fatty acid oxidation, P:hepoxilin biosynthetic process, P:leukotriene A4 metabolic process, P:linoleic acid metabolic process, P:lipoxin A4 biosynthetic process, P:lipoxin B4 biosynthetic process, P:lipoxygenase pathway, P:negative regulation of muscle cell apoptotic process, P:negative regulation of platelet aggregation, P:positive regulation of angiogenesis, P:positive regulation of apoptotic process, P:positive regulation of cell adhesion, P:positive regulation of cell growth, P:positive regulation of cell migration, P:positive regulation of cell proliferation, P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:positive regulation of endothelial cell differentiation, P:positive regulation of endothelial cell migration, P:positive regulation of gene expression, P:positive regulation of mitochondrial depolarization, P:positive regulation of smooth muscle cell proliferation, P:positive regulation of vasodilation, P:superoxide anion generation, "F:metal ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen", F:lipoxygenase activity, P:leukotriene biosynthetic process, P:negative regulation of apoptotic process, P:negative regulation of cell killing, P:positive regulation of cell killing, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
UniProt3D-structure, Complete proteome, Cytoplasm, Dioxygenase, Fatty acid metabolism, Hydrolase, Iron, Lipid metabolism, Membrane, Metal-binding, Oxidoreductase, Polymorphism, Reference proteome, Leukotriene biosynthesis
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.715.32E-0320136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.613.26E-0221886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.302.65E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.722.86E-0322252466

Compile date 09-07-2016© MuScle project