MuScle-logoMuScle - Molecule ID B8129

geneAK3L1, AK3L2, AK3
nameAdenylate kinase isoenzyme 4, mitochondrial
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
KAD4_HUMANP27144ENSG00000162433100507855Hs.10862103030

Functions and classifications

GOC:mitochondrial matrix, F:adenylate kinase activity, F:ATP binding, F:GTP binding, F:nucleoside diphosphate kinase activity, F:nucleoside triphosphate adenylate kinase activity, P:AMP metabolic process, P:ATP metabolic process, P:brain development, P:GTP metabolic process, P:liver development, P:nucleoside triphosphate biosynthetic process, P:response to drug, P:nucleotide phosphorylation, P:response to organic cyclic compound, P:response to organic nitrogen, C:mitochondrion
UniProt3D-structure, Acetylation, ATP-binding, Complete proteome, GTP-binding, Kinase, Mitochondrion, Nucleotide-binding, Reference proteome, Transferase
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_2_days_follow-up) (Multiple sclerosis)0.663.26E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)0.620.0113528920136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.200.00953121886806
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.230.03453122252466
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.290.02766622252466
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.380.004694122252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.458.35E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.551.92E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.593.21E-0622252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.011.73E-0622252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)4.001.02E-1022252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.530.0456007422491253
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)3.130.002841222491253
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.954.97E-0223895517

Compile date 09-07-2016© MuScle project