MuScle-logoMuScle - Molecule ID B7083

geneALAS1, ALAS3, ALASH
name5-aminolevulinic acid synthase, nonspecific, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
HEM1_HUMANP13196ENSG00000023330211Hs.476308125290

Functions and classifications

GOC:mitochondrial matrix, C:nucleus, F:5-aminolevulinate synthase activity, F:pyridoxal phosphate binding, P:cellular lipid metabolic process, P:heme biosynthetic process, P:protoporphyrinogen IX biosynthetic process, P:small molecule metabolic process, F:catalytic activity, P:biosynthetic process, P:porphyrin-containing compound metabolic process, P:tetrapyrrole biosynthetic process, C:mitochondrion, F:transferase activity
UniProtAcyltransferase, Alternative splicing, Complete proteome, Heme biosynthesis, Mitochondrion, Pyridoxal phosphate, Reference proteome, Transferase, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.446.79E-0317467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.158.98E-0320136355
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.143.75E-0222021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.674.63E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.494.29E-0522252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.383.32E-0523895517

Compile date 09-07-2016© MuScle project