MuScle-logoMuScle - Molecule ID B4650

geneADAR, ADAR1, DSRAD
nameDouble-stranded RNA-specific adenosine deaminase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
DSRAD_HUMANP55265ENSG00000160710103Hs.12341127400, 146920, 615010, 601059

Functions and classifications

GOC:cytoplasm, C:nucleolus, C:nucleoplasm, C:nucleus, C:supraspliceosomal complex, F:DNA binding, F:double-stranded RNA adenosine deaminase activity, F:metal ion binding, F:RNA binding, P:adenosine to inosine editing, P:defense response to virus, P:gene expression, P:gene silencing by RNA, P:mRNA modification, P:mRNA processing, P:negative regulation of apoptotic process, P:negative regulation of protein kinase activity by regulation of protein phosphorylation, P:positive regulation of viral genome replication, P:protein export from nucleus, P:protein import into nucleus, P:response to interferon-alpha, P:response to virus, P:type I interferon signaling pathway, P:RNA processing, F:double-stranded RNA binding, P:type I interferon-mediated signaling pathway, C:intracellular
UniProt3D-structure, Aicardi-Goutieres syndrome, Alternative promoter usage, Alternative splicing, Antiviral defense, Complete proteome, Cytoplasm, Direct protein sequencing, Disease mutation, DNA-binding, Hydrolase, Immunity, Innate immunity, Isopeptide bond, Metal-binding, mRNA processing, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, RNA-binding, RNA-mediated gene silencing, Ubl conjugation, Zinc
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.621.94E-0417467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_6_month_follow-up) (Multiple sclerosis)1.654.70E-0417467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.309.10E-0820136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.150.0313021520136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.220.0012536820136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.520.0148446721886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.490.002676421886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.871.77E-0521886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)1.390.006634821886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.440.0050208721886806
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.761.59E-0222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.516.07E-0422252466

Compile date 09-07-2016© MuScle project