MuScle-logoMuScle - Molecule ID B3949

geneCX3CR1, CMKBRL1, GPR13
nameCX3C chemokine receptor 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CX3C1_HUMANP49238ENSG000001683291524Hs.78913601470, 609423, 613784

Functions and classifications

GOC:integral component of plasma membrane, C:neuron projection, C:neuronal cell body membrane, C:perinuclear region of cytoplasm, F:C-X3-C chemokine receptor activity, F:chemokine receptor activity, P:cell adhesion, P:cellular defense response, P:cellular response to lipopolysaccharide, P:cellular response to transforming growth factor beta stimulus, P:cerebral cortex cell migration, P:chemotaxis, P:macrophage chemotaxis, P:microglial cell activation involved in immune response, P:negative regulation of angiogenesis, P:negative regulation of cell migration, P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:positive regulation of angiogenesis, P:response to wounding, P:viral process, C:integral component of membrane, P:chemokine-mediated signaling pathway, C:integral to plasma membrane, P:negative regulation of apoptotic process, P:virus-host interaction, C:integral to membrane
UniProtAge-related macular degeneration, Alternative splicing, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Host-virus interaction, Membrane, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBRCP: receptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.622.85E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.520.0283091721886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.212.67E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.493.84E-0322021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.022.48E-1322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)2.992.54E-0323895517

Compile date 09-07-2016© MuScle project