MuScle-logoMuScle - Molecule ID B1087

geneASCL2, BHLHA45, HASH2
nameAchaete-scute homolog 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ASCL2_HUMANQ99929ENSG00000183734430Hs.152475601886

Functions and classifications

GOC:cytoplasm, C:nucleus, F:E-box binding, F:sequence-specific DNA binding, F:sequence-specific DNA binding transcription factor activity, P:central nervous system development, P:negative regulation of Schwann cell proliferation, P:negative regulation of transcription from RNA polymerase II promoter, P:peripheral nervous system development, P:response to hypoxia, P:somatic stem cell maintenance, P:spongiotrophoblast differentiation, P:spongiotrophoblast layer development, P:transcription, DNA-templated, P:transcription, DNA-dependent"
UniProtComplete proteome, Developmental protein, Differentiation, DNA-binding, Neurogenesis, Nucleus, Reference proteome
PADBDEV: development, cell growth, differentiation, morphogenesis

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)0.442.62E-0517467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)1.302.91E-0220136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.904.47E-0521886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)1.420.0242292421886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.889.74E-0322021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.420.023976622252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.251.38E-1022252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.914.44E-0222252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.105.00E-0323895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.421.12E-0223895517
Exp24850724Homo sapiens12Blood CIS (Multiple sclerosis)2.840.0293857624850724

Compile date 09-07-2016© MuScle project