MuScle-logoMuScle - Molecule ID B0944

geneARHGEF7, COOL1, P85SPR
nameRho guanine nucleotide exchange factor 7
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHG7_HUMANQ14155ENSG000001026068874Hs.508738605477

Functions and classifications

GOC:cell cortex, C:cytosol, C:focal adhesion, C:lamellipodium, C:neuron projection, C:neuronal cell body, C:protein complex, C:ruffle, F:guanyl-nucleotide exchange factor activity, F:Rho guanyl-nucleotide exchange factor activity, P:apoptotic signaling pathway, P:epidermal growth factor receptor signaling pathway, P:lamellipodium assembly, P:negative regulation of epidermal growth factor receptor signaling pathway, P:nervous system development, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of GTPase activity, P:regulation of Rho GTPase activity, P:small GTPase mediated signal transduction, P:intracellular signal transduction, F:phospholipid binding, P:apoptotic process, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, P:regulation of small GTPase mediated signal transduction, C:intracellular
UniProt3D-structure, Alternative splicing, Cell junction, Cell projection, Complete proteome, Cytoplasm, Guanine-nucleotide releasing factor, Neurogenesis, Phosphoprotein, Polymorphism, Reference proteome, SH3 domain
PADBMOD: modulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)1.820.000157320921521
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)2.460.023850820921521
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)3.120.013319220921521
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.468.28E-0622021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.811.03E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.821.76E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.875.89E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.933.83E-0222021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.213.20E-0222252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.102.14E-0223895517

Compile date 09-07-2016© MuScle project