MuScle-logoMuScle - Molecule ID B0856

geneAPOC2, APC2
nameApolipoprotein C-II precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC2_HUMANP02655ENSG00000234906344Hs.75615207750, 608083

Functions and classifications

GOC:chylomicron, C:early endosome, C:intermediate-density lipoprotein particle, C:low-density lipoprotein particle, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:lipase inhibitor activity, F:lipid binding, F:lipoprotein lipase activator activity, F:phospholipase activator activity, F:protein homodimerization activity, P:cholesterol efflux, P:cholesterol homeostasis, P:chylomicron remnant clearance, P:chylomicron remodeling, P:high-density lipoprotein particle clearance, P:lipid catabolic process, P:lipoprotein metabolic process, P:lipoprotein transport, P:negative regulation of cholesterol transport, P:negative regulation of lipid metabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of lipoprotein lipase activity, P:positive regulation of phospholipase activity, P:positive regulation of phospholipid catabolic process, P:positive regulation of triglyceride catabolic process, P:positive regulation of very-low-density lipoprotein particle remodeling, P:response to drug, P:retinoid metabolic process, P:reverse cholesterol transport, P:small molecule metabolic process, P:triglyceride homeostasis, P:very-low-density lipoprotein particle remodeling, F:enzyme activator activity, P:lipid metabolic process, P:lipid transport, P:positive regulation of catalytic activity
UniProt3D-structure, Chylomicron, Complete proteome, Direct protein sequencing, Disease mutation, Hyperlipidemia, Lipid degradation, Lipid metabolism, Lipid transport, Polymorphism, Reference proteome, Secreted, Signal, Transport, VLDL
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.922.39E-0222021740
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.859.28E-0422252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.152.83E-0222252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.430.007631422491253
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)1.890.042147522491253
Exp24850724Homo sapiens12Blood CIS (Multiple sclerosis)1.810.0144222424850724

Compile date 09-07-2016© MuScle project