MuScle-logoMuScle - Molecule ID B0855

geneAPOC1, APOC1B
nameApolipoprotein C-I precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOC1_HUMANP02654ENSG00000130208341Hs.110675107710

Functions and classifications

GOC:chylomicron, C:endoplasmic reticulum, C:high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:fatty acid binding, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipase inhibitor activity, P:cholesterol efflux, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:high-density lipoprotein particle remodeling, P:lipid metabolic process, P:lipoprotein metabolic process, P:negative regulation of cholesterol transport, P:negative regulation of fatty acid biosynthetic process, P:negative regulation of lipoprotein lipase activity, P:negative regulation of phosphatidylcholine catabolic process, P:negative regulation of receptor-mediated endocytosis, P:negative regulation of very-low-density lipoprotein particle clearance, P:phospholipid efflux, P:positive regulation of cholesterol esterification, P:triglyceride metabolic process, P:very-low-density lipoprotein particle assembly, P:very-low-density lipoprotein particle clearance, C:extracellular region, P:regulation of lipid transport
UniProt3D-structure, Complete proteome, Direct protein sequencing, Lipid transport, Polymorphism, Reference proteome, Secreted, Signal, Transport, VLDL, Lipoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.830.01490521886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)15.036.28E-1022252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)16.561.07E-0922252466
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)3.770.025638622491253

Compile date 09-07-2016© MuScle project