MuScle-logoMuScle - Molecule ID B0850

geneAPOA2
nameApolipoprotein A-II precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOA2_HUMANP02652ENSG00000158874336Hs.237658107670

Functions and classifications

GOC:chylomicron, C:cytosol, C:early endosome, C:endoplasmic reticulum lumen, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:cholesterol binding, F:cholesterol transporter activity, F:high-density lipoprotein particle binding, F:lipase inhibitor activity, F:lipid transporter activity, F:phosphatidylcholine binding, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:protein homodimerization activity, P:acute inflammatory response, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:diacylglycerol catabolic process, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:negative regulation of cholesterol import, P:negative regulation of cholesterol transporter activity, P:negative regulation of cytokine secretion involved in immune response, P:negative regulation of lipase activity, P:negative regulation of lipid catabolic process, P:negative regulation of very-low-density lipoprotein particle remodeling, P:organ regeneration, P:peptidyl-methionine modification, P:phosphatidylcholine biosynthetic process, P:phospholipid catabolic process, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of cholesterol esterification, P:positive regulation of interleukin-8 biosynthetic process, P:positive regulation of lipid catabolic process, P:protein folding, P:protein oxidation, P:regulation of intestinal cholesterol absorption, P:regulation of protein stability, P:response to drug, P:response to estrogen, P:response to glucocorticoid, P:response to glucose, P:retinoid metabolic process, P:reverse cholesterol transport, P:triglyceride metabolic process, P:triglyceride-rich lipoprotein particle remodeling, P:viral process, P:response to estrogen stimulus, P:response to glucocorticoid stimulus, P:response to glucose stimulus, P:virus-host interaction
UniProt3D-structure, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, HDL, Host-virus interaction, Lipid transport, Oxidation, Phosphoprotein, Pyrrolidone carboxylic acid, Reference proteome, Secreted, Signal, Transport, Lipoprotein
PADBTP: transport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50BloodRRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)0.570.040309420136355
Exp21886806Homo sapiens12BloodRRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.321.78E-0221886806
Exp21886806Homo sapiens12BloodRRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.331.07E-0221886806
Exp22491253Homo sapiens7BloodRRMS_(Low_Sema4A) (Multiple sclerosis)6.980.014577322491253

Compile date 09-07-2016© MuScle project