MuScle-logoMuScle - Molecule ID B0840

geneAPH-1b, APH1B, PSFL
nameGamma-secretase subunit APH-1B
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APH1B_HUMANQ8WW43ENSG0000013861383464Hs.511703607630

Functions and classifications

GOC:integral component of membrane, C:plasma membrane, C:transport vesicle, F:peptidase activity, P:apoptotic signaling pathway, P:membrane protein intracellular domain proteolysis, P:neurotrophin TRK receptor signaling pathway, P:Notch receptor processing, P:Notch signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of catalytic activity, P:protein processing, C:integral to membrane, P:apoptotic process, P:nerve growth factor receptor signaling pathway
UniProtAlternative splicing, Complete proteome, Membrane, Notch signaling pathway, Polymorphism, Reference proteome, Transmembrane, Transmembrane helix
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.144.22E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.243.35E-0322021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.345.74E-1322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.122.00E-0223895517

Compile date 09-07-2016© MuScle project