MuScle-logoMuScle - Molecule ID B0838

geneAPEX2, APE2, APEXL2
nameDNA-(apurinic or apyrimidinic site) lyase 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APEX2_HUMANQ9UBZ4ENSG0000016918827301Hs.659558300773

Functions and classifications

GOC:mitochondrial inner membrane, C:nucleus, F:DNA binding, F:DNA-(apurinic or apyrimidinic site) lyase activity, F:endonuclease activity, F:exonuclease activity, F:zinc ion binding, P:cell cycle, P:DNA recombination, P:DNA repair, P:nucleic acid phosphodiester bond hydrolysis, C:intracellular, F:lyase activity, F:nuclease activity, F:metal ion binding
UniProtCell cycle, Complete proteome, Cytoplasm, DNA damage, DNA recombination, DNA repair, DNA-binding, Endonuclease, Exonuclease, Hydrolase, Lyase, Magnesium, Metal-binding, Mitochondrion, Nuclease, Nucleus, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.320.030309322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.104.28E-0223895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.141.33E-0323895517

Compile date 09-07-2016© MuScle project