MuScle-logoMuScle - Molecule ID B0837

geneAPEX1, APE, APEX
nameDNA-(apurinic or apyrimidinic site) lyase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APEX1_HUMANP27695ENSG00000100823328Hs.73722107748

Functions and classifications

GOC:centrosome, C:endoplasmic reticulum, C:mitochondrion, C:nuclear speck, C:nucleolus, C:perinuclear region of cytoplasm, C:ribosome, C:transcription factor complex, F:3'-5' exonuclease activity, F:chromatin DNA binding, F:damaged DNA binding, F:DNA-(apurinic or apyrimidinic site) lyase activity, F:metal ion binding, F:oxidoreductase activity, F:phosphodiesterase I activity, F:RNA binding, F:RNA-DNA hybrid ribonuclease activity, F:site-specific endodeoxyribonuclease activity, specific for altered base, F:transcription coactivator activity, F:transcription corepressor activity, F:uracil DNA N-glycosylase activity, P:aging, P:base-excision repair, P:cell redox homeostasis, P:cellular response to cAMP, P:cellular response to hydrogen peroxide, P:cellular response to peptide hormone stimulus, P:DNA demethylation, P:DNA recombination, P:negative regulation of smooth muscle cell migration, P:positive regulation of DNA repair, P:positive regulation of G1/S transition of mitotic cell cycle, P:regulation of mRNA stability, P:regulation of transcription, DNA-templated, P:response to drug, P:transcription, DNA-templated, C:nucleus, F:DNA binding, F:endonuclease activity, P:DNA repair, P:nucleic acid phosphodiester bond hydrolysis, "C:mitochondrion, F:endoribonuclease activity, P:RNA phosphodiester bond hydrolysis, endonucleolytic", C:intracellular, F:ribonuclease H activity, P:regulation of transcription, DNA-dependent, P:transcription, DNA-dependent", C:cytoplasm
UniProt3D-structure, Acetylation, Activator, Cleavage on pair of basic residues, Complete proteome, Cytoplasm, Direct protein sequencing, Disulfide bond, DNA damage, DNA recombination, DNA repair, DNA-binding, Endonuclease, Endoplasmic reticulum, Exonuclease, Hydrolase, Lyase, Magnesium, Metal-binding, Mitochondrion, Nuclease, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repressor, RNA-binding, S-nitrosylation, Transcription, Transcription regulation, Ubl conjugation, Plasmid
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.841.17E-0320136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.880.0240268620136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.767.29E-0420136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)0.680.002975321886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.615.21E-0421886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_3_month_follow-up) (Multiple sclerosis)0.740.0053440521886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)3.781.06E-1122252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)4.327.33E-1422252466
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)4.250.008291322491253

Compile date 09-07-2016© MuScle project