MuScle-logoMuScle - Molecule ID B0833

geneANAPC5, APC5, PDL-108
nameAnaphase promoting complex subunit 5
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APC5_HUMANQ9UJX4ENSG00000089053|ENSG0000027220451433Hs.7101606948

Functions and classifications

GOC:anaphase-promoting complex, C:cytosol, C:nucleoplasm, F:ubiquitin-protein ligase activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:G2/M transition of mitotic cell cycle, P:mitosis, P:mitotic anaphase, P:mitotic spindle assembly checkpoint, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein K11-linked ubiquitination, P:cell division, P:mitotic cell cycle spindle assembly checkpoint
UniProtAlternative splicing, Cell cycle, Cell division, Complete proteome, Mitosis, Phosphoprotein, Polymorphism, Reference proteome, Repeat, TPR repeat, Ubl conjugation pathway
PADBCC: cell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.879.31E-0320136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.861.77E-0320136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.832.62E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.824.71E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.858.23E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.861.93E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.213.11E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.359.73E-0322021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.647.59E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.165.83E-0922252466

Compile date 09-07-2016© MuScle project