MuScle-logoMuScle - Molecule ID B0832

geneANAPC4, APC4
nameAnaphase promoting complex subunit 4
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APC4_HUMANQ9UJX5ENSG0000005390029945Hs.152173606947

Functions and classifications

GOC:anaphase-promoting complex, C:cytosol, C:nucleoplasm, F:ubiquitin-protein ligase activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:G2/M transition of mitotic cell cycle, P:mitosis, P:mitotic anaphase, P:mitotic spindle assembly checkpoint, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein K11-linked ubiquitination, P:regulation of mitotic metaphase/anaphase transition, P:cell division, P:mitotic cell cycle spindle assembly checkpoint
UniProtAlternative splicing, Cell cycle, Cell division, Complete proteome, Mitosis, Phosphoprotein, Polymorphism, Reference proteome, Ubl conjugation pathway
PADBCC: cell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.883.10E-0220136355
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)1.280.033726520921521
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.869.59E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.872.04E-0222021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)0.650.028311622252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.811.52E-0223895517

Compile date 09-07-2016© MuScle project