MuScle-logoMuScle - Molecule ID B0824

geneAPC, DP2.5
nameAdenomatous polyposis coli protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APC_HUMANP25054ENSG00000134982|ENSG00000258864324Hs.158932114550, 135290, 155255, 175100, 276300, 611731, 613659

Functions and classifications

GOC:adherens junction, C:axonal growth cone, C:beta-catenin destruction complex, C:centrosome, C:cytoplasmic microtubule, C:cytosol, C:kinetochore, C:lamellipodium, C:lateral plasma membrane, C:microtubule plus-end, C:nucleus, C:ruffle membrane, C:tight junction, F:microtubule plus-end binding, F:protein kinase regulator activity, P:anterior/posterior pattern specification, P:axis specification, P:axonogenesis, P:canonical Wnt signaling pathway, P:canonical Wnt signaling pathway involved in negative regulation of apoptotic process, P:canonical Wnt signaling pathway involved in positive regulation of apoptotic process, P:cell adhesion, P:cell cycle arrest, P:cell migration, P:cellular component disassembly involved in execution phase of apoptosis, P:cellular response to DNA damage stimulus, P:chromosome organization, P:cytoplasmic microtubule organization, P:dorsal/ventral pattern formation, P:hair follicle development, P:kidney development, P:metaphase/anaphase transition of mitotic cell cycle, P:mitotic cytokinesis, P:mitotic spindle assembly checkpoint, P:muscle cell cellular homeostasis, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of cell proliferation, P:negative regulation of cyclin-dependent protein serine/threonine kinase activity, P:negative regulation of epithelial cell proliferation involved in prostate gland development, P:negative regulation of MAPK cascade, P:negative regulation of microtubule depolymerization, P:negative regulation of odontogenesis, P:positive regulation of apoptotic process, P:positive regulation of cell adhesion, P:positive regulation of cell division, P:positive regulation of cell migration, P:positive regulation of epithelial cell differentiation, P:positive regulation of microtubule polymerization, P:positive regulation of protein catabolic process, P:positive regulation of pseudopodium assembly, P:protein complex assembly, P:proximal/distal pattern formation, P:regulation of attachment of spindle microtubules to kinetochore, P:regulation of nitrogen compound metabolic process, P:regulation of osteoblast differentiation, P:regulation of osteoclast differentiation, P:retina development in camera-type eye, P:somatic stem cell maintenance, P:T cell differentiation in thymus, P:thymus development, P:tight junction assembly, C:cytoplasm, P:negative regulation of Wnt signaling pathway, P:Wnt signaling pathway, C:cell projection membrane, C:microtubule plus end, C:neuronal cell body, C:synapse, P:canonical Wnt receptor signaling pathway, P:cytokinesis after mitosis, P:establishment or maintenance of cell polarity, P:mitotic cell cycle spindle assembly checkpoint, P:mitotic metaphase/anaphase transition, P:muscle cell homeostasis, P:negative regulation of apoptotic process, P:negative regulation of canonical Wnt receptor signaling pathway, P:negative regulation of cyclin-dependent protein kinase activity, P:pancreas development, P:response to DNA damage stimulus, P:response to drug, P:skin development, P:negative regulation of Wnt receptor signaling pathway, P:Wnt receptor signaling pathway
UniProt3D-structure, Acetylation, Alternative splicing, Cell junction, Cell membrane, Cell projection, Coiled coil, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Membrane, Microtubule, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Tumor suppressor, Ubl conjugation, Wnt signaling pathway
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.350.0318438121886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.571.83E-0221886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.280.04369121886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.207.88E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.271.07E-0422021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.282.18E-0422021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.706.90E-0522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.769.00E-0322252466
Exp22491253Homo sapiens7Blood RRMS_(High_Sema4A) (Multiple sclerosis)0.370.0446986722491253
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.849.95E-0323895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.892.61E-0223895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.159.24E-0323895517

Compile date 09-07-2016© MuScle project