MuScle-logoMuScle - Molecule ID B0816

geneAPAF1
nameApoptotic protease activating factor 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APAF_HUMANO14727ENSG00000120868317Hs.552567602233

Functions and classifications

GOC:apoptosome, C:Golgi apparatus, C:nucleus, F:ADP binding, F:ATP binding, F:cysteine-type endopeptidase activator activity involved in apoptotic process, F:nucleotide binding, P:activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, P:apoptotic DNA fragmentation, P:defense response, P:forebrain development, P:intrinsic apoptotic signaling pathway, P:nervous system development, P:neural tube closure, P:neuron apoptotic process, P:positive regulation of apoptotic process, P:positive regulation of apoptotic signaling pathway, P:response to G1 DNA damage checkpoint signaling, C:intracellular, P:regulation of apoptotic process
UniProt3D-structure, Alternative splicing, Apoptosis, ATP-binding, Calcium, Complete proteome, Cytoplasm, Direct protein sequencing, Nucleotide-binding, Reference proteome, Repeat, WD repeat
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.628.12E-0321886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.241.77E-0322021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.623.20E-1022021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.827.22E-0722021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.302.72E-0822252466

Compile date 09-07-2016© MuScle project