MuScle-logoMuScle - Molecule ID B0763

geneANXA1, ANX1, LPC1
nameAnnexin A1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANXA1_HUMANP04083ENSG00000135046301Hs.494173151690

Functions and classifications

GOC:basolateral plasma membrane, C:cilium, C:cornified envelope, C:cytoplasm, C:extracellular space, C:extracellular vesicular exosome, C:mitochondrial membrane, C:nucleus, C:plasma membrane, C:protein complex, C:sarcolemma, F:calcium ion binding, F:calcium-dependent phospholipid binding, F:phospholipase A2 inhibitor activity, F:protein binding, bridging, F:receptor binding, F:structural molecule activity, P:alpha-beta T cell differentiation, P:arachidonic acid secretion, P:cell surface receptor signaling pathway, P:cellular component movement, P:cellular response to glucocorticoid stimulus, P:cellular response to hydrogen peroxide, P:endocrine pancreas development, P:estrous cycle phase, P:gliogenesis, P:hepatocyte differentiation, P:inflammatory response, P:insulin secretion, P:keratinocyte differentiation, P:negative regulation of acute inflammatory response, P:negative regulation of apoptotic process, P:negative regulation of protein secretion, P:neutrophil clearance, P:peptide cross-linking, P:positive regulation of G1/S transition of mitotic cell cycle, P:positive regulation of neutrophil apoptotic process, P:positive regulation of prostaglandin biosynthetic process, P:positive regulation of vesicle fusion, P:regulation of cell proliferation, P:response to drug, P:response to estradiol, P:response to interleukin-1, P:response to peptide hormone, P:response to X-ray, P:negative regulation of catalytic activity, P:neutrophil homeostasis, P:response to X-ray, F:phospholipase inhibitor activity, F:single-stranded DNA binding, F:single-stranded RNA binding, P:cell cycle, P:positive regulation of apoptotic process, P:response to estradiol stimulus, P:response to peptide hormone stimulus, P:response to glucocorticoid stimulus
UniProt3D-structure, Acetylation, Annexin, Calcium, Calcium/phospholipid-binding, Cell membrane, Cell projection, Cilium, Complete proteome, Cytoplasm, Direct protein sequencing, Isopeptide bond, Membrane, Nucleus, Phospholipase A2 inhibitor, Phosphoprotein, Reference proteome, Repeat
PADBINH: inhibitor (protease, kinase, other enzymes, pathways)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20921521Homo sapiens10Blood PPMS_(PRF1_gene_Risk_haplotype) (Multiple sclerosis)0.830.044930720921521
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)2.892.14E-0422021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.633.83E-0422252466

Compile date 09-07-2016© MuScle project