MuScle-logoMuScle - Molecule ID B0675

geneANK2
nameAnkyrin 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANK2_HUMANQ01484ENSG00000145362287Hs.620557106410, 600919

Functions and classifications

GOC:apical plasma membrane, C:basolateral plasma membrane, C:costamere, C:cytoskeleton, C:cytosol, C:integral component of plasma membrane, C:intercalated disc, C:M band, C:membrane raft, C:neuron projection, C:perinuclear region of cytoplasm, C:postsynaptic membrane, C:T-tubule, C:Z disc, F:ATPase binding, F:ion channel binding, F:potassium channel regulator activity, F:protein binding, bridging, F:structural constituent of cytoskeleton, P:atrial septum development, P:axon guidance, P:cardiac muscle contraction, P:cellular calcium ion homeostasis, P:membrane depolarization involved in regulation of SA node cell action potential, P:paranodal junction assembly, P:positive regulation of calcium ion transmembrane transporter activity, P:positive regulation of calcium ion transport, P:positive regulation of cation channel activity, P:positive regulation of gene expression, P:positive regulation of potassium ion transmembrane transporter activity, P:positive regulation of potassium ion transport, P:protein localization to cell surface, P:protein localization to endoplasmic reticulum, P:protein localization to M-band, P:protein localization to T-tubule, P:protein stabilization, P:protein targeting to plasma membrane, P:regulation of atrial cardiac muscle cell action potential, P:regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion, P:regulation of heart rate by cardiac conduction, P:regulation of ventricular cardiac muscle cell action potential, P:regulation of ventricular cardiac muscle cell membrane repolarization, P:response to methylmercury, P:sarcoplasmic reticulum calcium ion transport, P:T-tubule organization, P:signal transduction, P:regulation of cardiac muscle contraction by calcium ion signaling, P:regulation of SA node cell action potential, P:T-tubule organization, C:integral to plasma membrane, P:protein localization to plasma membrane, C:cytoplasm
UniProt3D-structure, Alternative splicing, ANK repeat, Cell junction, Cell membrane, Complete proteome, Cytoplasm, Cytoskeleton, Disease mutation, Long QT syndrome, Membrane, Phosphoprotein, Polymorphism, Postsynaptic cell membrane, Reference proteome, Repeat, Synapse
PADBCS: Cell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.412.60E-0220136355
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.060.0113090721216829
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.130.0203889821216829

Compile date 09-07-2016© MuScle project