MuScle-logoMuScle - Molecule ID B0669

geneANGPT1, AngA
nameAngiopoietin-1 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANGP1_HUMANQ15389ENSG00000154188284Hs.369675601667

Functions and classifications

GOC:extracellular space, C:membrane raft, C:microvillus, C:plasma membrane, P:activation of transmembrane receptor protein tyrosine kinase activity, P:blood coagulation, P:cell differentiation, P:cell-substrate adhesion, P:glomerulus vasculature development, P:hemopoiesis, P:heparin biosynthetic process, P:in utero embryonic development, P:leukocyte migration, P:negative regulation of cell adhesion, P:negative regulation of endothelial cell apoptotic process, P:negative regulation of neuron apoptotic process, P:negative regulation of vascular permeability, P:positive chemotaxis, P:positive regulation of blood vessel endothelial cell migration, P:positive regulation of cell adhesion, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of phosphatidylinositol 3-kinase signaling, P:positive regulation of protein kinase B signaling, P:positive regulation of protein ubiquitination, P:positive regulation of receptor internalization, P:protein localization to cell surface, P:regulation of satellite cell proliferation, P:sprouting angiogenesis, P:Tie signaling pathway, P:angiogenesis, P:transmembrane receptor protein tyrosine kinase signaling pathway, P:organ regeneration, P:ovarian follicle development, P:positive regulation of phosphatidylinositol 3-kinase cascade, P:positive regulation of protein kinase B signaling cascade, P:protein homooligomerization, P:response to estrogen stimulus, P:response to hypoxia, P:response to vitamin B3, P:Tie receptor signaling pathway, P:signal transduction
UniProt3D-structure, Alternative splicing, Angiogenesis, Coiled coil, Complete proteome, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Polymorphism, Reference proteome, Secreted, Signal
PADBSIG: signalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.712.09E-0220136355
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.744.91E-0221886806
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)0.560.048804222252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.555.34E-0722252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)11.163.93E-0822252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)18.772.64E-0922252466

Compile date 09-07-2016© MuScle project