MuScle-logoMuScle - Molecule ID B0653

geneANAPC2, APC2
nameAnaphase promoting complex subunit 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANC2_HUMANQ9UJX6ENSG0000017624829882Hs.533262606946

Functions and classifications

GOC:anaphase-promoting complex, C:cytosol, C:nucleoplasm, F:ubiquitin-protein ligase activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:cyclin catabolic process, P:mitosis, P:mitotic spindle assembly checkpoint, P:negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:positive regulation of axon extension, P:positive regulation of dendrite morphogenesis, P:positive regulation of synapse maturation, P:positive regulation of synaptic plasticity, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein K11-linked ubiquitination, P:regulation of cyclin-dependent protein serine/threonine kinase activity, C:nucleus, C:cullin-RING ubiquitin ligase complex, P:ubiquitin-dependent protein catabolic process, P:cell division, P:mitotic cell cycle spindle assembly checkpoint, P:regulation of cyclin-dependent protein kinase activity
UniProtAlternative splicing, Cell cycle, Cell division, Complete proteome, Differentiation, Mitosis, Neurogenesis, Phosphoprotein, Reference proteome, Ubl conjugation pathway
PADBCC: cell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.752.68E-0222252466
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.240.037956322252466
Exp22491253Homo sapiens7Blood RRMS_(Low_Sema4A) (Multiple sclerosis)0.290.005775622491253

Compile date 09-07-2016© MuScle project