MuScle-logoMuScle - Molecule ID B0577

geneALKBH3, ABH3, DEPC1
nameAlpha-ketoglutarate-dependent dioxygenase ALKB homolog 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALKB3_HUMANQ96Q83ENSG00000166199221120Hs.720708610603

Functions and classifications

GOC:mitochondrion, C:nucleoplasm, F:DNA-N1-methyladenine dioxygenase activity, F:ferrous iron binding, F:L-ascorbic acid binding, P:cell proliferation, P:DNA dealkylation involved in DNA repair, P:oxidative single-stranded DNA demethylation, "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors", C:nucleus, "C:mitochondrion, F:cytosine C-5 DNA demethylase activity, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, P:oxidative single-stranded DNA demethylation", F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors", "F:cytosine C-5 DNA demethylase activity
UniProt3D-structure, Alternative splicing, Complete proteome, Cytoplasm, Dioxygenase, DNA damage, DNA repair, Iron, Metal-binding, Nucleus, Oxidoreductase, Polymorphism, Reference proteome, Vitamin C
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21216829Homo sapiens8BloodCD8+RRMS_(CD8+) (Multiple sclerosis)0.370.0235507121216829
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)0.901.40E-0322021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.817.33E-0922252466

Compile date 09-07-2016© MuScle project