MuScle-logoMuScle - Molecule ID B0576

geneALKBH2, ABH2
nameAlpha-ketoglutarate-dependent dioxygenase ALKB homolog 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALKB2_HUMANQ6NS38ENSG00000189046121642Hs.374458610602

Functions and classifications

GOC:nucleoplasm, F:cytosine C-5 DNA demethylase activity, F:DNA-N1-methyladenine dioxygenase activity, F:ferrous iron binding, P:DNA dealkylation involved in DNA repair, P:oxidative DNA demethylation, "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, P:oxidation-reduction process", "C:nucleoplasm, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, P:oxidative DNA demethylation", "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors"
UniProt3D-structure, Alternative splicing, Complete proteome, Dioxygenase, DNA damage, DNA repair, Iron, Magnesium, Metal-binding, Nucleus, Oxidoreductase, Polymorphism, Reference proteome
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)0.732.12E-0221886806
Exp22252466AHomo sapiens13BloodCD34- HPCRRMS_SPMS (Multiple sclerosis)0.844.90E-0222252466
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.200.029334522252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.033.76E-0922252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)2.384.59E-0322252466

Compile date 09-07-2016© MuScle project