MuScle-logoMuScle - Molecule ID B0575

geneALKBH1, ABH, ABH1
nameAlkylated DNA repair protein alkB homolog 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALKB1_HUMANQ13686ENSG000001006018846Hs.94542605345

Functions and classifications

GOC:mitochondrion, C:nuclear euchromatin, F:chemoattractant activity, F:DNA-(apurinic or apyrimidinic site) lyase activity, F:ferrous iron binding, F:methylcytosine dioxygenase activity, P:developmental growth, P:DNA dealkylation involved in DNA repair, P:DNA demethylation, P:in utero embryonic development, P:negative regulation of neuron apoptotic process, P:neuron migration, P:neuron projection development, P:oxidative demethylation, P:placenta development, P:RNA repair, "F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors, P:DNA repair", "C:mitochondrion, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, P:RNA repair"
UniProtComplete proteome, Dioxygenase, DNA damage, DNA repair, Iron, Lyase, Metal-binding, Mitochondrion, Multifunctional enzyme, Nucleus, Oxidoreductase, Polymorphism, Reference proteome, RNA repair
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_24_month_follow-up) (Multiple sclerosis)1.300.009550821886806
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_3_month_follow-up) (Multiple sclerosis)1.321.56E-0221886806
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.171.23E-0222021740
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.251.75E-0422021740
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.861.75E-0222252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.054.62E-0223895517
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.127.85E-0323895517

Compile date 09-07-2016© MuScle project