MuScle-logoMuScle - Molecule ID B0574

geneALK
nameALK tyrosine kinase receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALK_HUMANQ9UM73ENSG00000171094238Hs.654469105590, 613014

Functions and classifications

GOC:integral component of plasma membrane, F:ATP binding, F:NF-kappaB-inducing kinase activity, F:transmembrane receptor protein tyrosine kinase activity, P:activation of MAPK activity, P:cell proliferation, P:neuron development, P:positive regulation of NF-kappaB transcription factor activity, P:protein autophosphorylation, P:regulation of apoptotic process, P:transmembrane receptor protein tyrosine kinase signaling pathway, P:nervous system development, C:integral component of membrane, P:peptidyl-tyrosine phosphorylation, F:kinase activity, C:integral to plasma membrane, C:integral to membrane
UniProt3D-structure, ATP-binding, Cell membrane, Chromosomal rearrangement, Complete proteome, Disease mutation, Glycoprotein, Kinase, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, Receptor, Reference proteome, Repeat, Signal, Transferase, Transmembrane, Transmembrane helix, Tyrosine-protein kinase
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)1.603.04E-0217467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)3.924.71E-0617467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_6_month_follow-up) (Multiple sclerosis)3.391.65E-0417467740
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.620.0058908420136355
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.042.53E-0223895517

Compile date 09-07-2016© MuScle project