MuScle-logoMuScle - Molecule ID B0568

geneALG2, UNQ666/PRO1298, UNQ666
nameAlpha-1,3-mannosyltransferase ALG2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ALG2_HUMANQ9H553ENSG0000011952385365Hs.40919607905, 607906

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, C:nucleus, C:perinuclear region of cytoplasm, F:alpha-1,3-mannosyltransferase activity, F:calcium-dependent protein binding, F:GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity, F:glycolipid 6-alpha-mannosyltransferase activity, F:protein anchor, P:dolichol-linked oligosaccharide biosynthetic process, P:post-translational protein modification, P:protein glycosylation in endoplasmic reticulum, P:protein N-linked glycosylation via asparagine, P:response to calcium ion, "F:GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity, P:biosynthetic process, P:mannosylation", C:integral to membrane, "F:transferase activity, transferring glycosyl groups, P:biosynthetic process"
UniProtAlternative splicing, Complete proteome, Congenital disorder of glycosylation, Glycosyltransferase, Membrane, Polymorphism, Reference proteome, Transferase, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)0.861.31E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_12_month_follow-up) (Multiple sclerosis)1.324.07E-0220136355
Exp22021740Homo sapiens27Blood MS (Multiple sclerosis)1.348.70E-0622021740
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.350.048257822252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.755.83E-0322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)1.163.46E-0223895517

Compile date 09-07-2016© MuScle project