MuScle-logoMuScle - Molecule ID B0550

geneALOX5AP, FLAP
nameArachidonate 5-lipoxygenase-activating protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL5AP_HUMANP20292ENSG00000132965241Hs.507658601367, 603700, 608557

Functions and classifications

GOC:cytosol, C:endoplasmic reticulum, C:endoplasmic reticulum membrane, C:integral component of membrane, C:nuclear membrane, F:arachidonic acid binding, F:enzyme activator activity, P:arachidonic acid metabolic process, P:cellular response to calcium ion, P:leukotriene biosynthetic process, P:leukotriene production involved in inflammatory response, P:lipoxin metabolic process, P:lipoxygenase pathway, P:positive regulation of acute inflammatory response, P:positive regulation of catalytic activity, P:protein homotrimerization, C:integral to membrane, F:arachidonate 5-lipoxygenase activity, F:glutathione peroxidase activity, F:glutathione transferase activity, P:glutathione biosynthetic process
UniProt3D-structure, Complete proteome, Endoplasmic reticulum, Leukotriene biosynthesis, Membrane, Nucleus, Reference proteome, Transmembrane, Transmembrane helix
PADBCC: cell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22252466AHomo sapiens13BloodCD34+ HPCRRMS_SPMS (Multiple sclerosis)1.390.003200622252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.131.35E-0922252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.143.43E-0922252466

Compile date 09-07-2016© MuScle project