MuScle-logoMuScle - Molecule ID B0549

geneALDH4A1, ALDH4, P5CDH
nameDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AL4A1_HUMANP30038ENSG000001594238659Hs.77448239510, 606811

Functions and classifications

GOC:mitochondrial matrix, F:1-pyrroline-5-carboxylate dehydrogenase activity, F:aldehyde dehydrogenase (NAD) activity, F:electron carrier activity, P:4-hydroxyproline catabolic process, P:cellular nitrogen compound metabolic process, P:proline biosynthetic process, P:proline catabolic process, P:proline catabolic process to glutamate, F:oxidoreductase activity, "F:1-pyrroline-5-carboxylate dehydrogenase activity, F:oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor"
UniProt3D-structure, Acetylation, Alternative splicing, Complete proteome, Direct protein sequencing, Disease mutation, Mitochondrion, NAD, Oxidoreductase, Polymorphism, Proline metabolism, Reference proteome, Transit peptide
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_1_month_follow-up) (Multiple sclerosis)0.762.16E-0220136355
Exp20136355Homo sapiens50Blood RRMS_(rIFN-Beta-1b_24_month_follow-up) (Multiple sclerosis)0.750.0227819120136355
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.406.37E-0322252466
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)1.927.42E-0522252466

Compile date 09-07-2016© MuScle project