MuScle-logoMuScle - Molecule ID B0531

geneAKT1, PKB, RAC
nameRAC-alpha serine/threonine kinase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AKT1_HUMANP31749ENSG00000142208207Hs.525622114480, 114500, 164730, 176920, 615109

Functions and classifications

GOC:cytosol, C:microtubule cytoskeleton, C:nucleoplasm, C:plasma membrane, C:spindle, F:ATP binding, F:enzyme binding, F:nitric-oxide synthase regulator activity, F:phosphatidylinositol-3,4,5-trisphosphate binding, F:phosphatidylinositol-3,4-bisphosphate binding, F:protein serine/threonine kinase activity, P:activation-induced cell death of T cells, P:aging, P:anagen, P:apoptotic mitochondrial changes, P:cell projection organization, P:cell proliferation, P:cellular response to epidermal growth factor stimulus, P:cellular response to hypoxia, P:cellular response to mechanical stimulus, P:endocrine pancreas development, P:epidermal growth factor receptor signaling pathway, P:execution phase of apoptosis, P:Fc-epsilon receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:G-protein coupled receptor signaling pathway, P:gene expression, P:germ cell development, P:glucose homeostasis, P:glucose metabolic process, P:glucose transport, P:glycogen biosynthetic process, P:glycogen cell differentiation involved in embryonic placenta development, P:hyaluronan metabolic process, P:inflammatory response, P:innate immune response, P:insulin receptor signaling pathway, P:insulin-like growth factor receptor signaling pathway, P:intrinsic apoptotic signaling pathway, P:labyrinthine layer blood vessel development, P:mammary gland epithelial cell differentiation, P:maternal placenta development, P:mRNA metabolic process, P:negative regulation of apoptotic process, P:negative regulation of autophagy, P:negative regulation of cell size, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:negative regulation of extrinsic apoptotic signaling pathway in absence of ligand, P:negative regulation of fatty acid beta-oxidation, P:negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stress, P:negative regulation of JNK cascade, P:negative regulation of plasma membrane long-chain fatty acid transport, P:negative regulation of protein kinase activity, P:negative regulation of proteolysis, P:negative regulation of release of cytochrome c from mitochondria, P:neurotrophin TRK receptor signaling pathway, P:nitric oxide biosynthetic process, P:osteoblast differentiation, P:peptidyl-serine phosphorylation, P:peripheral nervous system myelin maintenance, P:phosphatidylinositol-mediated signaling, P:platelet activation, P:positive regulation of apoptotic process, P:positive regulation of blood vessel endothelial cell migration, P:positive regulation of cell growth, P:positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle, P:positive regulation of endothelial cell proliferation, P:positive regulation of establishment of protein localization to plasma membrane, P:positive regulation of fat cell differentiation, P:positive regulation of glucose import, P:positive regulation of glycogen biosynthetic process, P:positive regulation of lipid biosynthetic process, P:positive regulation of nitric oxide biosynthetic process, P:positive regulation of nitric-oxide synthase activity, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process, P:positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, P:positive regulation of sequence-specific DNA binding transcription factor activity, P:positive regulation of sodium ion transport, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of vasoconstriction, P:protein autophosphorylation, P:protein catabolic process, P:protein import into nucleus, translocation, P:protein kinase B signaling, P:protein ubiquitination, P:regulation of cell cycle checkpoint, P:regulation of neuron projection development, P:regulation of translation, P:response to fluid shear stress, P:response to food, P:response to heat, P:response to UV-A, P:small molecule metabolic process, P:striated muscle cell differentiation, P:T cell costimulation, P:translation, C:cytosol, C:nucleus, F:protein kinase activity, P:cellular response to insulin stimulus, P:regulation of cell migration, P:regulation of protein localization, P:translation, C:lamellipodium, P:nerve growth factor receptor signaling pathway, P:positive regulation of cyclin-dependent protein kinase activity involved in G1/S, P:protein kinase B signaling cascade, P:regulation of G1/S transition checkpoint, F:phospholipid binding
UniProt3D-structure, Acetylation, Apoptosis, ATP-binding, Carbohydrate metabolism, Cell membrane, Complete proteome, Cytoplasm, Developmental protein, Disease mutation, Disulfide bond, Glucose metabolism, Glycogen biosynthesis, Glycogen metabolism, Glycoprotein, Kinase, Membrane, Neurogenesis, Nucleotide-binding, Nucleus, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, Serine/threonine-protein kinase, Sugar transport, Transferase, Translation regulation, Transport, Ubl conjugation
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseFold change in diseaseP-valuePubMed/DOI
Exp22021740Homo sapiens27BloodMS (Multiple sclerosis)1.564.50E-0622021740

Compile date 09-07-2016© MuScle project