MuScle-logoMuScle - Molecule ID B0515

geneAKAP6, AKAP100
nameA-kinase anchor protein 6
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:calcium channel complex, C:caveola, C:intercalated disc, C:junctional sarcoplasmic reticulum membrane, C:nuclear envelope, C:nuclear membrane, C:perinuclear region of cytoplasm, C:T-tubule, F:adenylate cyclase binding, F:protein anchor, F:protein complex scaffold, F:protein kinase A regulatory subunit binding, P:cAMP-mediated signaling, P:cellular response to cAMP, P:cellular response to cytokine stimulus, P:negative regulation of cAMP biosynthetic process, P:positive regulation of calcineurin-NFAT signaling cascade, P:positive regulation of cell growth involved in cardiac muscle cell development, P:positive regulation of delayed rectifier potassium channel activity, P:positive regulation of NFAT protein import into nucleus, P:positive regulation of potassium ion transmembrane transport, P:positive regulation of protein phosphatase type 2B activity, P:positive regulation of release of sequestered calcium ion into cytosol, P:positive regulation of ryanodine-sensitive calcium-release channel activity, P:protein targeting, P:regulation of action potential, P:regulation of membrane repolarization, P:regulation of protein kinase A signaling, P:regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum, F:kinase activity, C:nuclear outer membrane, C:sarcoplasmic reticulum, F:protein kinase A binding, P:regulation of protein kinase A signaling cascade, C:protein complex
UniProtComplete proteome, Membrane, Nucleus, Polymorphism, Reference proteome, Repeat, Sarcoplasmic reticulum, Kinase, Transferase
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)9.336.13E-1017467740
Exp17467740Homo sapiens10Blood RRMS_(IFN-Beta-1a_6_month_follow-up) (Multiple sclerosis)3.721.50E-0417467740
Exp21886806Homo sapiens12Blood RRMS_(IFN-Beta-1a_12_month_follow-up) (Multiple sclerosis)1.190.0218982721886806
Exp22252466AHomo sapiens16BloodCD34+/CD34- HPCRRMS_SPMS (Multiple sclerosis)0.789.32E-0322252466
Exp23895517AHomo sapiens19BloodT-cellsRRMS_(relapsing-remitting_MS) (Multiple sclerosis)0.941.09E-0223895517

Compile date 09-07-2016© MuScle project