MuScle-logoMuScle - Molecule ID B0505

geneAKR1D1, SRD5B1
name3-oxo-5-beta-steroid 4-dehydrogenase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
AK1D1_HUMANP51857ENSG000001227876718Hs.201667235555, 604741

Functions and classifications

GOC:cytosol, F:delta4-3-oxosteroid 5beta-reductase activity, F:steroid binding, P:androgen metabolic process, P:bile acid biosynthetic process, P:bile acid catabolic process, P:C21-steroid hormone metabolic process, P:cholesterol catabolic process, P:digestion, P:oxidation-reduction process, F:oxidoreductase activity, F:3-oxo-5-beta-steroid 4-dehydrogenase activity
UniProt3D-structure, Alternative splicing, Bile acid catabolism, Complete proteome, Cytoplasm, Disease mutation, Intrahepatic cholestasis, Lipid degradation, Lipid metabolism, NADP, Oxidoreductase, Reference proteome, Steroid metabolism
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceDiseaseFold change in diseaseP-valuePubMed/DOI
Exp17467740Homo sapiens10BloodRRMS_(IFN-Beta-1a_1_day_follow-up) (Multiple sclerosis)2.361.07E-0217467740
Exp21346816Homo sapiens12BloodMS (Multiple sclerosis)1.140.04796121346816

Compile date 09-07-2016© MuScle project